Preferred di-tert-butyl azodicarboxylate is used for nucleoside compound synthesis
2023/8/10
5'-S-(4,4'-dimethoxytrityl)-2'-deoxyinosine is used as an intermediate for introducing heteroatom sulfur modification to the 2'-deoxyinosine sugar group, and the modified compound It has been confirmed that it has obvious effects in improving the biological activity of the drug, increasing the antiviral spectrum, and reducing toxic and side effects.
In the synthesis method of 5′-S-(4,4′-dimethoxytrityl)-2′-deoxyinosine, the azo reagent played a crucial role.
Due to the following advantages, di-tert-butyl azodicarboxylate will be preferred for Mitsunobu reaction (光式 reaction):
1. The reaction conditions are mild;
2. There are few by-products, because the selectivity of the reaction is high;
3. No corrosive materials are used in the whole preparation process, which reduces the toxicity of the operation process;
4. The source of raw materials is wide, so the cost of synthesizing the target product is relatively low;
5. The yield of the target product is high, up to 90% or more;
6. The preparation process is simple, the post-processing is convenient, and it is suitable for large-scale industrial production.
With the deepening of research, the new nucleoside compounds obtained after functional group transformation and modification of nucleoside compounds and their derivatives are useful in the treatment of cardiovascular diseases, central nervous system diseases, circulatory and urinary system diseases, as well as antiviral and antitumor. It has a special curative effect and is widely used in molecular biology, medicine and other fields.
Di-tert-butyl azodicarboxylate will also play an important role in industrial production and has broad application prospects.
The di-tert-butyl azodicarboxylate produced by Nanjing Shunxiang has the characteristics of high content, good stability and high packaging safety. Rich experience in production and transportation makes the di-tert-butyl azodicarboxylate produced by Nanjing Shunxiang deeply trusted and praised by domestic and foreign customers, and has established a strategic partnership with well-known domestic and foreign pharmaceutical companies. Nanjing Shunxiang is modernizing Advanced technology, excellent product quality, high-quality service, and competitive prices serve our customers.
JIN DUN CHEMICAL has built a special (meth) acrylic monomer manufacturing base in ZHEJIANG province. This makes sure the stable supply of HEMA, HPMA, HEA, HPA, GMA with high level quality. Our special acrylate monomers are widely used for thermosetting acrylic resins, crosslinkable emulsion polymers, acrylate anaerobic adhesive, two-component acrylate adhesive, solvent acrylate adhesive, emulsion acrylate adhesive, paper finishing agent and painting acrylic resins in adhesive.We have also developed the new and special (meth) acrylic monomers and derivatives. Such as the fluorinated acrylate monomers, It can be widely used in coating leveling agent, paints, inks, photosensitive resins, optical materials, fiber treatment, modifier for plastic or rubber field. We are aiming to be the top supplier in the field of special acrylate monomers, to share our rich experience with better quality products and professional service.
